New Study Indicates Oral Bacteria May Increase Heart Disease Risk

CHINNAPONG / STOCK.ADOBE.COM

A new study published this week in eLife, a not-for-profit, peer-reviewed, open access, scientific journal for the biomedical and life sciences, suggests another potential risk factor that physicians might screen for to identify individuals at risk of heart disease. The study may also indicate that treatments for colonization or infection with the oral bacterium Fusobacterium nucleatum may help reduce heart disease risk.

A combination of genetic and environmental risk factors contributes to heart disease, which is responsible for about one-third of all deaths world‐wide. A build-up of plaque in the arteries that supply the heart with blood causes coronary heart disease—the most common type of heart disease—and can also lead to blockages that cause heart attacks. Previous studies have linked certain infections to an increased risk of plaque build-up, according to a press release issued this week by ScienceDaily.

"Although enormous progress has been made in understanding how coronary heart disease develops, our understanding of how infections, inflammation, and genetic risk factors contribute is still incomplete," says the study’s lead author Flavia Hodel, former PhD student at the School of Life Sciences of EPFL, Switzerland. "We wanted to help fill some of the gaps in our understanding of coronary heart disease by taking a more comprehensive look at the role of infections."

Hodel and colleagues analyzed genetic information, health data, and blood samples from a subset of 3,459 people who participated in the CoLaus|PsyCoLaus Study—a Swiss population-based cohort. Of the 3,459 participants, around 6% experienced a heart attack or another harmful cardiovascular event during the 12-year follow-up period, the study indicates. The team tested participants' blood samples for the presence of antibodies against 15 different viruses, 6 bacteria, and 1 parasite.

Once the authors adjusted the results for known cardiovascular risk factors, they found that antibodies against F. nucleatum, a sign of previous or current infection by the bacterium, were linked with a slightly increased risk of a cardiovascular event.

"F. nucleatum might contribute to cardiovascular risk through increased systemic inflammation due to bacterial presence in the mouth, or through direct colonization of the arterial walls or plaque lining the arterial walls," Hodel explains.

The researchers also confirmed that individuals with high genetic risk scores for coronary heart disease are at elevated risk for cardiovascular events, as previous studies have shown.

If future studies confirm the link between F. nucleatum and heart disease, the authors say it may lead to new approaches to identifying those at risk or preventing cardiovascular events.

"Our study adds to growing evidence that inflammation triggered by infections may contribute to the development of coronary heart disease and increase the risk of a heart attack," concludes senior author Jacques Fellay, a professor at the School of Life Sciences, EPFL, and head of the Precision Medicine Unit at Lausanne University Hospital and the University of Lausanne, Switzerland. "Our results may lead to new ways of identifying high-risk individuals or lay the groundwork for studies of preventive interventions that treat F. nucleatum infections to protect the heart."

This study is just the latest in the last several years that indicates the impact oral health has on overall health. The American Academy for Oral Systemic Health (AAOSH), for example, is one of many organizations whose focus is on expanding awareness of the relationship between oral health and whole body health. AAOSH membership includes and is open to health professionals from many allied health disciplines, corporate supporters and sponsors, health educators, and healthcare leaders.

To watch a video on the oral-systemic link from Dental Products Report®, click here.